CLINICAL STUDIES ON PERIODIC PARALYSIS. IV

Thyrotoxic Periodic Paralysis: Clinical Challenges

Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis. Factors like high-carbohydrate meal exercise, steroid, and stress can precipi...

Thyrotoxic Periodic Paralysis – Clinical Diagnosis and Management

Thyrotoxic periodic paralysis: clinical and molecular aspects.

Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism that most often affects young East Asian males but increasingly also in other ethnic groups. The typical presentation is acute attacks varying from mild weakness to total paralysis starting at night or in the early morning a few hours after a heavy meal, alcohol abuse or strenuous exercise with complete recovery withi...

Familial Periodic Paralysis

Familial periodic paralysis is a malady usually characterized by (1) recurrent flaccid muscular paralysis, (2) history of the disease in other members of the family, (3) depression of the level of potassium ions in the blood serum during an episode of paresis, (4) impairment of electrical excitability of the musculature, (5) impairment of deep reflexes, (6) retention of consciousness without al...

Hyperthyroid hypokalemic periodic paralysis

Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like pr...